Spring Books: When the bowels turn to water

It’s Spring, and Thoughts Turn to … Allergies

synthesized either directly (e.g., leukotrienes) or after activation of specific genes (e.g., for interleukins). These mediators mobilize an array of cellular and molecular Henry Metzger Arthritis and Rheumatism Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases weaponry that constitutes the immune and inflammatory National Institutes of Health systems. Bethesda, Maryl...

Turn to TCRs when CARs fail

The past few years have brought exciting progress in the development of novel forms of immunotherapy of cancer. While antibody blockade of negative pathways that inhibit T cell function, such as CTLA-4 and PD1, has resulted in clinical benefits for patients who have failed conventional therapy options, this strategy lacks cancer specificity as it also activates T cells with selfreactive potenti...

To the Framingham data, turn, turn, turn.

Bacterial Pathogenesis: When a turn off is a turn on

Pathogenic bacteria express distinct sets of genes at different stages in their life cycles; inappropriate expression of normally repressed genes during host colonization can interfere with bacterial survival.

Mug Books : When Does Adding Multimedia Help ?

To provide better customer service, NCJRS has made this Federally-funded grant final report available electronically in addition to traditional paper copies. Opinions or points of view expressed are those of the author(s) and do not necessarily reflect the official position or policies of the U.S. Department of Justice.